In order to obtain a specific signal in the Serum CrossLaps ® (CTX-I) ELISA, two chains of EKAHD-ß-GGR must be cross-linked.Īs of late 2010, IOF and IFCC (International Federation of Clinical Chemistry and Laboratory Medicine) recommend the serum CTX-I as a bone resorption marker for use in observational and intervention studies, in order to compare the performance of alternatives and to widen international experience of the application of bone markers to clinical medicine 3. The Serum CrossLaps ® (CTX-I) ELISA is based on two highly specific monoclonal antibodies against the amino acid sequence of EKAHD-ß-GGR, where the aspartic acid residue (D) is ß-isomerised. Serum levels of these degradation products, such as CTX-I, are highly correlated with the bone turnover rate and allow an assessment of the rate of bone resorption. During renewal of the skeleton, Type I collagen is degraded and small peptide fragments are excreted into the bloodstream. Type I collagen accounts for more than 90% of the organic matrix of bone and is synthesised primarily in bone. SRL Diagnostics is a leading blood test laboratory of India to book test online for home collection and check lab test results with just a couple of clicks.

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